抗炎症効果（IL -１Ra)と、成長因子(PDGF, FGF,TGF-b VEGF,EGF)と共同して組織の再生を行います。
Autologous Cytokine Rich Serum 自己血サイトカインリッチ血清とは、炎症免疫療法です。ドイツのSanakinという製品を使用し、血小板を含む血液成分をガラス、ポリーマーなどの人工表面に粘着させ、放出させます。
その特徴は①血清療法 ②活性化した血小板由来成分 ③血小板からの自然放出反応を導く ④通常血中濃度の約５倍のサイトカイン量
閉経や更年期、内分泌障害、感染、外傷などにより増床し、また加齢とともに老化した細胞が蓄積し起こすと、炎症性サイトカインのIL-α及びIl-1betaが分泌されます。Il-1は年齢と共に増加することが知られています。その影響で脱毛、老化（しわ）、アルツハイマー病、パーキンソン病、心臓病などの加齢性疾患が引き起こされることが知られています。そこで、炎症性サイトカインIL-αの拮抗物質であるIl-1Raを投与することで、IL-1受容体接続をブロックし、炎症を抑えます。
Below is an English summary and explanation of Autologous Cytokine Rich Serum (ACRS), also known as “Sanakin” therapy, based on the information provided:
What is ACRS?
ACRS (Autologous Cytokine Rich Serum) is a form of immunotherapy that utilizes the patient’s own blood (autologous blood). By activating platelets and inducing them to release high concentrations of cytokines and growth factors, it aims to reduce inflammation and promote tissue regeneration. In Germany, a product called Sanakin is often used to facilitate this process.
Key Features of ACRS
- Serum Therapy
ACRS involves collecting the patient’s own blood and processing it to obtain a serum rich in cytokines (particularly IL-1Ra, an anti-inflammatory cytokine) and growth factors. - Activated Platelet-Derived Components
The therapy harnesses components derived from activated platelets, which naturally release beneficial factors when they come into contact with certain surfaces. - Induction of Platelets’ Natural Release Reaction
Glass or polymer surfaces are used to adhere and activate platelets, prompting them to release various cytokines and growth factors. - High Cytokine Concentration
The resultant serum is said to have approximately five times the normal blood concentration of cytokines, enhancing its potential therapeutic effect.
Mechanism of Action
- Anti-Inflammatory Cytokines (IL-1Ra)
As we age—or due to hormonal changes (e.g., menopause), endocrine disorders, infections, or injuries—pro-inflammatory cytokines such as IL-1α and IL-1β increase. IL-1 is known to rise with age, contributing to conditions like hair loss, wrinkles, Alzheimer’s disease, Parkinson’s disease, heart disease, and other age-related disorders.- IL-1Ra (IL-1 receptor antagonist) in ACRS blocks IL-1 from binding to its receptor, thereby reducing inflammation.
- Growth Factors (PDGF, FGF, TGF-β, VEGF, EGF)
ACRS contains various growth factors, which help repair and regenerate tissues. These include:- PDGF (Platelet-Derived Growth Factor)
- FGF (Fibroblast Growth Factor)
- TGF-β (Transforming Growth Factor-β)
- VEGF (Vascular Endothelial Growth Factor)
- EGF (Epidermal Growth Factor)
These factors promote cell growth, collagen production, and angiogenesis (formation of new blood vessels), all of which support tissue repair and regeneration.
Potential Benefits and Applications
- Inflammation Control
By blocking IL-1 receptors, ACRS can help manage and reduce inflammation in various conditions, such as osteoarthritis, tendon injuries, and other inflammatory disorders. - Tissue Regeneration & Anti-Aging
The high concentration of growth factors can potentially accelerate wound healing, improve skin quality (e.g., reducing wrinkles), and address hair loss. It may also offer supportive therapy in neurodegenerative and cardiovascular conditions by controlling inflammatory processes. - Lower Risk of Allergic Reactions
Because this therapy uses the patient’s own blood, there is a lower risk of immune rejection or serious allergic responses.
Summary
ACRS (Autologous Cytokine Rich Serum) is a regenerative therapy that utilizes naturally released cytokines and growth factors from a patient’s own activated platelets. It is particularly notable for its anti-inflammatory action (through IL-1Ra) and its high concentration of growth factors, offering a dual approach: controlling harmful inflammation while promoting tissue repair. This makes it a promising option in various medical fields, from orthopedics and sports medicine to dermatology and anti-aging treatments.
